CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.718 | Isopropylmalate Dehydrogenase |
|
3.40.718.10 | Isopropylmalate Dehydrogenase |
Domain Context
CATH Clusters
| Superfamily | Isopropylmalate Dehydrogenase |
| Functional Family | 3-isopropylmalate dehydrogenase |
Enzyme Information
| 1.1.1.85 |
3-isopropylmalate dehydrogenase.
based on mapping to UniProt Q5SIY4
(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO(2) + NADH.
|
UniProtKB Entries (1)
| Q5SIY4 |
LEU3_THET8
Thermus thermophilus HB8
3-isopropylmalate dehydrogenase
|
PDB Structure
| PDB | 4WUO |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Glutamate 270 plays an essential role in K(+)-activation and domain closure of Thermus thermophilus isopropylmalate dehydrogenase.
Febs Lett.
|