CATH Domain 4wabA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.120	Four Helix Bundle (Hemerythrin (Met), subunit A)
	1.20.120.550	Membrane associated eicosanoid/glutathione metabolism-like domain

Domain Context

CATH Clusters

Superfamily	Membrane associated eicosanoid/glutathione metabolism-like domain
Functional Family	Microsomal glutathione S-transferase 1

Enzyme Information

5.3.99.3	Prostaglandin-E synthase. based on mapping to UniProt O14684 (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate. -!- Brings about the opening of the epidioxy bridge.
4.4.1.20	Leukotriene-C(4) synthase. based on mapping to UniProt Q16873 Leukotriene C(4) = leukotriene A(4) + glutathione. -!- The reaction proceeds in the direction of addition. -!- Not identical with EC 2.5.1.18. -!- Formerly EC 2.5.1.37.

UniProtKB Entries (1)

PTGES_HUMAN

Homo sapiens

Prostaglandin E synthase

PDB Structure

PDB	4WAB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Fast native-SAD phasing for routine macromolecular structure determination. Weinert, T., Olieric, V., Waltersperger, S., Panepucci, E., Chen, L., Zhang, H., Zhou, D., Rose, J., Ebihara, A., Kuramitsu, S., Li, D., Howe, N., Schnapp, G., Pautsch, A., Bargsten, K., Prota, A.E., Surana, P., Kottur, J., Nair, D.T., Basilico, F., Cecatiello, V., Pasqualato, S., Boland, A., Weichenrieder, O., Wang, B.C., Steinmetz, M.O., Caffrey, M., Wang, M. Nat.Methods