CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.418 | Actin-binding Protein, T-fimbrin; domain 1 | |
1.10.418.10 | Calponin-like domain |
Domain Context
CATH Clusters
Superfamily | Calponin-like domain |
Functional Family | F-actin-methionine sulfoxide oxidase MICAL1 isoform X1 |
Enzyme Information
1.14.13.225 |
F-actin monooxygenase.
based on mapping to UniProt Q8VDP3
[F-actin]-L-methionine + NADPH + O(2) + H(+) = [F-actin]-L-methionine- (R)-S-oxide + NADP(+) + H(2)O.
-!- The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor. -!- The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization. -!- Free methionine is not a substrate. -!- The reaction is stereospecific and generates the (R)-sulfoxide.
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UniProtKB Entries (1)
Q8VDP3 |
MICA1_MOUSE
Mus musculus
[F-actin]-monooxygenase MICAL1
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PDB Structure
PDB | 4TXK |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural insights into modulation of MICAL activity by its Calponin Homology (CH) domain
To Be Published
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