CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclin-like
Functional Family

Enzyme Information

UniProtKB Entries (2)

Q01043
CGH2_SHV21
Herpesvirus saimiri (strain 11)
Cyclin homolog
Q00534
CDK6_HUMAN
Homo sapiens
Cyclin-dependent kinase 6

PDB Structure

PDB 4TTH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Li, Z., Wang, X., Eksterowicz, J., Gribble, M.W., Alba, G.Q., Ayres, M., Carlson, T.J., Chen, A., Chen, X., Cho, R., Connors, R.V., DeGraffenreid, M., Deignan, J.T., Duquette, J., Fan, P., Fisher, B., Fu, J., Huard, J.N., Kaizerman, J., Keegan, K.S., Li, C., Li, K., Li, Y., Liang, L., Liu, W., Lively, S.E., Lo, M.C., Ma, J., McMinn, D.L., Mihalic, J.T., Modi, K., Ngo, R., Pattabiraman, K., Piper, D.E., Queva, C., Ragains, M.L., Suchomel, J., Thibault, S., Walker, N., Wang, X., Wang, Z., Wanska, M., Wehn, P.M., Weidner, M.F., Zhang, A.J., Zhao, X., Kamb, A., Wickramasinghe, D., Dai, K., McGee, L.R., Medina, J.C.
J.Med.Chem.
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