CATH Domain 4totA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.100	Cyclophilin
	2.40.100.10	Cyclophilin-like

Domain Context

CATH Clusters

Superfamily	Cyclophilin-like
Functional Family	Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt P29117

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P29117

PPIF_RAT

Rattus norvegicus

Peptidyl-prolyl cis-trans isomerase F, mitochondrial

PDB Structure

PDB	4TOT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition. Fu, J., Tjandra, M., Becker, C., Bednarczyk, D., Capparelli, M., Elling, R., Hanna, I., Fujimoto, R., Furegati, M., Karur, S., Kasprzyk, T., Knapp, M., Leung, K., Li, X., Lu, P., Mergo, W., Miault, C., Ng, S., Parker, D., Peng, Y., Roggo, S., Rivkin, A., Simmons, R.L., Wang, M., Wiedmann, B., Weiss, A.H., Xiao, L., Xie, L., Xu, W., Yifru, A., Yang, S., Zhou, B., Sweeney, Z.K. J.Med.Chem.