CATH Domain 4ruaA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.270	Reverse transcriptase/Diguanylate cyclase domain

Domain Context

CATH Clusters

Superfamily	3.30.70.270
Functional Family	DNA polymerase IV

Enzyme Information

2.7.7.7

DNA-directed DNA polymerase.

based on mapping to UniProt Q97W02

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q97W02

DPO4_SACS2

Saccharolobus solfataricus P2

DNA polymerase IV

PDB Structure

PDB	4RUA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase eta and Sulfolobus solfataricus P2 Polymerase IV. Patra, A., Banerjee, S., Johnson Salyard, T.L., Malik, C.K., Christov, P.P., Rizzo, C.J., Stone, M.P., Egli, M. J.Am.Chem.Soc.