CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.10 | Orthogonal Bundle |
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1.10.1020 | Adenine-specific Methyltransferase; domain 2 |
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1.10.1020.10 | Adenine-specific Methyltransferase, Domain 2 |
Domain Context
CATH Clusters
Superfamily | Adenine-specific Methyltransferase, Domain 2 |
Functional Family | Site-specific DNA-methyltransferase (adenine-specific) |
Enzyme Information
2.1.1.72 |
Site-specific DNA-methyltransferase (adenine-specific).
based on mapping to UniProt P0AEE8
S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N-6-methyladenine in DNA.
-!- This is a large group of enzymes, most of which form so-called 'restriction-modification systems', with nucleases that possess similar site specificity (the nucleases are listed as either EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5). -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/
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UniProtKB Entries (1)
P0AEE8 |
DMA_ECOLI
Escherichia coli K-12
DNA adenine methylase
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PDB Structure
PDB | 4RTL |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structures of Escherichia coli DNA adenine methyltransferase (Dam) in complex with a non-GATC sequence: potential implications for methylation-independent transcriptional repression.
Nucleic Acids Res.
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