1 keywords

CATH Domain 4rmgA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1600 SIR2/SIRT2 'Small Domain'
Homologous Superfamily 3.30.1600.10 SIR2/SIRT2 'Small Domain'

Domain Context

CATH Clusters

Superfamily SIR2/SIRT2 'Small Domain'
Functional Family NAD-dependent deacetylase sirtuin-3, mitochondrial

Enzyme Information

3.5.1.-
In linear amides.
based on mapping to UniProt Q8IXJ6

UniProtKB Entries (1)

Q8IXJ6
SIR2_HUMAN
Homo sapiens
NAD-dependent protein deacetylase sirtuin-2

PDB Structure

PDB 4RMG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
Rumpf, T., Schiedel, M., Karaman, B., Roessler, C., North, B.J., Lehotzky, A., Olah, J., Ladwein, K.I., Schmidtkunz, K., Gajer, M., Pannek, M., Steegborn, C., Sinclair, D.A., Gerhardt, S., Ovadi, J., Schutkowski, M., Sippl, W., Einsle, O., Jung, M.
Nat Commun