CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1220 | TPP-binding domain |
Domain Context
CATH Clusters
| Superfamily | TPP-binding domain |
| Functional Family | NAD-dependent deacetylase sirtuin-2 |
Enzyme Information
| 3.5.1.- |
In linear amides.
based on mapping to UniProt Q8IXJ6
|
UniProtKB Entries (1)
| Q8IXJ6 |
SIR2_HUMAN
Homo sapiens
NAD-dependent protein deacetylase sirtuin-2
|
PDB Structure
| PDB | 4RMG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
Nat Commun
|