CATH Domain 4rlsC01

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	L-lactate dehydrogenase A chain

1.1.1.27

L-lactate dehydrogenase.

based on mapping to UniProt P00338

(S)-lactate + NAD(+) = pyruvate + NADH.

-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

LDHA_HUMAN

Homo sapiens

L-lactate dehydrogenase A chain

PDB	4RLS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase. Fauber, B.P., Dragovich, P.S., Chen, J., Corson, L.B., Ding, C.Z., Eigenbrot, C., Labadie, S., Malek, S., Peterson, D., Purkey, H.E., Robarge, K., Sideris, S., Ultsch, M., Wei, B., Yen, I., Yue, Q., Zhou, A. Bioorg.Med.Chem.Lett.