CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.60 | 4-Layer Sandwich |
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3.60.15 | Metallo-beta-lactamase; Chain A |
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3.60.15.10 | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
Domain Context
CATH Clusters
Superfamily | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
Functional Family | Metallo-beta-lactamase NDM-1 |
Enzyme Information
3.5.2.6 |
Beta-lactamase.
based on mapping to UniProt C7C422
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.
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UniProtKB Entries (1)
C7C422 |
BLAN1_KLEPN
Klebsiella pneumoniae
Metallo-beta-lactamase type 2
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PDB Structure
PDB | 4RL2 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis of Cephalosporins.
J.Am.Chem.Soc.
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