CATH Domain 4rioA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P52333

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P52333

JAK3_HUMAN

Homo sapiens

Tyrosine-protein kinase JAK3

PDB Structure

PDB	4RIO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors. Duan, J.J., Lu, Z., Jiang, B., Yang, B.V., Doweyko, L.M., Nirschl, D.S., Haque, L.E., Lin, S., Brown, G., Hynes, J., Tokarski, J.S., Sack, J.S., Khan, J., Lippy, J.S., Zhang, R.F., Pitt, S., Shen, G., Pitts, W.J., Carter, P.H., Barrish, J.C., Nadler, S.G., Salter-Cid, L.M., McKinnon, M., Fura, A., Schieven, G.L., Wrobleski, S.T. Bioorg.Med.Chem.Lett.