CATH Domain 4qwtA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.60	Lipoxygenase-1
	2.60.60.20	PLAT/LH2 domain

Domain Context

CATH Clusters

Superfamily	PLAT/LH2 domain
Functional Family

Enzyme Information

1.13.11.40

Arachidonate 8-lipoxygenase.

based on mapping to UniProt O16025

Arachidonate + O(2) = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14- tetraenoate.

-!- An enzyme from the coral Pseudoplexaura porosa.

4.2.1.92

Hydroperoxide dehydratase.

based on mapping to UniProt O16025

(9Z,11E,15Z)-(13S)-hydroperoxyoctadeca-9,11,15-trienoate = (9Z,15Z)- (13S)-12,13-epoxyoctadeca-9,11,15-trienoate + H(2)O.

-!- Acts on a number of unsaturated fatty-acid hydroperoxides, forming the corresponding allene oxides. -!- The product of the above reaction is unstable and is acted upon by EC 5.3.99.6 to form the cyclopentenone derivative (15Z)-12-oxophyto- 10,15-dienoate (OPDA), which is the first cyclic and biologically active metabolite in the jasmonate biosynthesis pathway.

UniProtKB Entries (1)

O16025

AOSL_PLEHO

Plexaura homomalla

Allene oxide synthase-lipoxygenase protein

PDB Structure

PDB	4QWT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of a Lipoxygenase in Complex with Substrate: THE ARACHIDONIC ACID-BINDING SITE OF 8R-LIPOXYGENASE. Neau, D.B., Bender, G., Boeglin, W.E., Bartlett, S.G., Brash, A.R., Newcomer, M.E. J.Biol.Chem.