CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.90 | Alpha-Beta Complex |
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3.90.70 | Cathepsin B; Chain A |
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3.90.70.10 | Cysteine proteinases |
Domain Context
CATH Clusters
Superfamily | Cysteine proteinases |
Functional Family | Papain |
Enzyme Information
3.4.22.2 |
Papain.
based on mapping to UniProt P00784
Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1'.
-!- From latex of the papaya (Carica papaya). -!- Inhibited by compound E-64 and proteins of the cystatin family. -!- Belongs to peptidase family C1. -!- Formerly EC 3.4.4.10.
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UniProtKB Entries (1)
P00784 |
PAPA1_CARPA
Carica papaya
Papain
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PDB Structure
PDB | 4QRG |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Pro-peptide regulates the substrate specificity and zymogen activation process of papain: A structural and mechanistic insight
To be Published
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