CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.640 | Aspartate Aminotransferase; domain 2 |
|
3.40.640.10 | Type I PLP-dependent aspartate aminotransferase-like (Major domain) |
Domain Context
CATH Clusters
| Superfamily | Type I PLP-dependent aspartate aminotransferase-like (Major domain) |
| Functional Family | sphingosine-1-phosphate lyase 1 |
Enzyme Information
| 4.1.2.27 |
Sphinganine-1-phosphate aldolase.
based on mapping to UniProt O95470
Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.
|
UniProtKB Entries (1)
| O95470 |
SGPL1_HUMAN
Homo sapiens
Sphingosine-1-phosphate lyase 1
|
PDB Structure
| PDB | 4Q6R |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Orally Active 7-Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1-Phosphate Lyase for the Treatment of Multiple Sclerosis.
J.Med.Chem.
|