CATH Domain 4q6rB02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1150	Aspartate Aminotransferase, domain 1
	3.90.1150.10	Aspartate Aminotransferase, domain 1

Domain Context

CATH Clusters

Superfamily	Aspartate Aminotransferase, domain 1
Functional Family	Sphingosine-1-phosphate lyase 1

Enzyme Information

4.1.2.27

Sphinganine-1-phosphate aldolase.

based on mapping to UniProt O95470

Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.

UniProtKB Entries (1)

SGPL1_HUMAN

Homo sapiens

Sphingosine-1-phosphate lyase 1

PDB Structure

PDB	4Q6R
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Orally Active 7-Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1-Phosphate Lyase for the Treatment of Multiple Sclerosis. Weiler, S., Braendlin, N., Beerli, C., Bergsdorf, C., Schubart, A., Srinivas, H., Oberhauser, B., Billich, A. J.Med.Chem.