CATH Domain 4q5vA05

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.132	Topoisomerase I; Chain A, domain 4
	1.10.132.60	DNA polymerase family B, C-terminal domain

Domain Context

CATH Clusters

Superfamily	DNA polymerase family B, C-terminal domain
Functional Family	DNA polymerase

Enzyme Information

2.7.7.7

DNA-directed DNA polymerase.

based on mapping to UniProt P09884

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P09884

DPOLA_HUMAN

Homo sapiens

DNA polymerase alpha catalytic subunit

PDB Structure

PDB	4Q5V
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for inhibition of DNA replication by aphidicolin. Baranovskiy, A.G., Babayeva, N.D., Suwa, Y., Gu, J., Pavlov, Y.I., Tahirov, T.H. Nucleic Acids Res.