CATH Domain 4pnzA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.140	8 Propeller
	2.140.10	Methanol Dehydrogenase; Chain A
	2.140.10.30	Dipeptidylpeptidase IV, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Dipeptidylpeptidase IV, N-terminal domain
Functional Family	Dipeptidyl peptidase 4

Enzyme Information

3.4.14.5

Dipeptidyl-peptidase IV.

based on mapping to UniProt P27487

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

-!- A membrane-bound serine-type peptidase in mammals. -!- EC 3.4.14.11 catalyzes a similar reaction. -!- Belongs to peptidase family S9B.

UniProtKB Entries (1)

P27487

DPP4_HUMAN

Homo sapiens

Dipeptidyl peptidase 4

PDB Structure

PDB	4PNZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes. Biftu, T., Sinha-Roy, R., Chen, P., Qian, X., Feng, D., Kuethe, J.T., Scapin, G., Gao, Y.D., Yan, Y., Krueger, D., Bak, A., Eiermann, G., He, J., Cox, J., Hicks, J., Lyons, K., He, H., Salituro, G., Tong, S., Patel, S., Doss, G., Petrov, A., Wu, J., Xu, S.S., Sewall, C., Zhang, X., Zhang, B., Thornberry, N.A., Weber, A.E. J.Med.Chem.