CATH Classification
Level | CATH Code | Description |
---|---|---|
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3 | Alpha Beta |
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3.90 | Alpha-Beta Complex |
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3.90.228 | Phosphoenolpyruvate Carboxykinase; domain 3 |
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3.90.228.10 |
Domain Context
CATH Clusters
Superfamily | 3.90.228.10 |
Functional Family | Poly [ADP-ribose] polymerase tankyrase-2 |
Enzyme Information
2.4.2.- |
Pentosyltransferases.
based on mapping to UniProt Q9H2K2
|
2.4.2.30 |
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt Q9H2K2
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
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UniProtKB Entries (1)
Q9H2K2 |
TNKS2_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase tankyrase-2
|
PDB Structure
PDB | 4PNS |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
Acta Crystallogr.,Sect.D
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