CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.50 | 3-Layer(bba) Sandwich |
|
3.50.50 | FAD/NAD(P)-binding domain |
|
3.50.50.60 | FAD/NAD(P)-binding domain |
Domain Context
CATH Clusters
| Superfamily | FAD/NAD(P)-binding domain |
| Functional Family | dimethylglycine dehydrogenase, mitochondrial |
Enzyme Information
| 1.5.8.4 |
Dimethylglycine dehydrogenase.
based on mapping to UniProt Q63342
N,N-dimethylglycine + 5,6,7,8-tetrahydrofolate + electron-transfer flavoprotein = sarcosine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein.
-!- An imine intermediate is channeled from the FAD binding site to the 5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel. -!- In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms formaldehyde. -!- Formerly EC 1.5.99.2.
|
UniProtKB Entries (1)
| Q63342 |
M2GD_RAT
Rattus norvegicus
Dimethylglycine dehydrogenase, mitochondrial
|
PDB Structure
| PDB | 4PAB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Folate in demethylation: The crystal structure of the rat dimethylglycine dehydrogenase complexed with tetrahydrofolate.
Biochem.Biophys.Res.Commun.
|
