CATH Domain 4p8qA03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.1910

Domain Context

CATH Clusters

Superfamily	2.60.40.1910
Functional Family	Leucyl-cystinyl aminopeptidase

Enzyme Information

3.4.11.3

Cystinyl aminopeptidase.

based on mapping to UniProt Q9UIQ6

Release of an N-terminal amino acid, Cys-|-Xaa-, in which the half- cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however.

-!- Belongs to peptidase family M1.

UniProtKB Entries (1)

Q9UIQ6

LCAP_HUMAN

Homo sapiens

Leucyl-cystinyl aminopeptidase

PDB Structure

PDB	4P8Q
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides. Hermans, S.J., Ascher, D.B., Hancock, N.C., Holien, J.K., Michell, B.J., Yeen Chai, S., Morton, C.J., Parker, M.W. Protein Sci.