CATH Domain 4ox2A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.449	Phosphoenolpyruvate Carboxykinase; domain 1
	3.40.449.10	Phosphoenolpyruvate Carboxykinase, domain 1

Domain Context

CATH Clusters

Superfamily	Phosphoenolpyruvate Carboxykinase, domain 1
Functional Family	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

Enzyme Information

4.1.1.32

Phosphoenolpyruvate carboxykinase (GTP).

based on mapping to UniProt P07379

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO(2).

-!- ITP can act as phosphate donor.

UniProtKB Entries (1)

PCKGC_RAT

Rattus norvegicus

Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

PDB Structure

PDB	4OX2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity. Adams, D.R., Yuan, H., Holyoak, T., Arajs, K.H., Hakimi, P., Markello, T.C., Wolfe, L.A., Vilboux, T., Burton, B.K., Fajardo, K.F., Grahame, G., Holloman, C., Sincan, M., Smith, A.C., Wells, G.A., Huang, Y., Vega, H., Snyder, J.P., Golas, G.A., Tifft, C.J., Boerkoel, C.F., Hanson, R.W., Traynelis, S.F., Kerr, D.S., Gahl, W.A. Mol.Genet.Metab.