CATH Domain 4owqA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1030	Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2
	3.40.1030.10	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain

Domain Context

CATH Clusters

Superfamily	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Functional Family	Anthranilate phosphoribosyltransferase

Enzyme Information

2.4.2.18

Anthranilate phosphoribosyltransferase.

based on mapping to UniProt P9WFX5

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.

-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).

UniProtKB Entries (1)

P9WFX5

TRPD_MYCTU

Mycobacterium tuberculosis H37Rv

Anthranilate phosphoribosyltransferase

PDB Structure

PDB	4OWQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis. Cookson, T.V., Castell, A., Bulloch, E.M., Evans, G.L., Short, F.L., Baker, E.N., Lott, J.S., Parker, E.J. Biochem.J.