CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.20 | Up-down Bundle |
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1.20.142 | Poly(ADP-ribose) Polymerase; domain 1 |
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1.20.142.10 | Poly(ADP-ribose) polymerase, regulatory domain |
Domain Context
CATH Clusters
Superfamily | Poly(ADP-ribose) polymerase, regulatory domain |
Functional Family | Poly [ADP-ribose] polymerase |
Enzyme Information
2.4.2.- |
Pentosyltransferases.
based on mapping to UniProt P09874
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2.4.2.30 |
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt P09874
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
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UniProtKB Entries (1)
P09874 |
PARP1_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase 1
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PDB Structure
PDB | 4OQA |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors.
J.Med.Chem.
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