CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Functional Family RNA demethylase ALKBH5

Enzyme Information

1.14.11.53
mRNA N(6)-methyladenine demethylase.
based on mapping to UniProt Q6P6C2
N(6)-methyladenosine in mRNA + 2-oxoglutarate + O(2) = adenosine in mRNA + formaldehyde + succinate + CO(2).
-!- Catalyzes oxidative demethylation of mRNA N(6)-methyladenine. -!- The FTO enzyme from human can also demethylate N(3)-methylthymine from single stranded DNA and N(3)-methyluridine from single stranded RNA with low activity.

UniProtKB Entries (1)

Q6P6C2
ALKB5_HUMAN
Homo sapiens
RNA demethylase ALKBH5

PDB Structure

PDB 4OCT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
Xu, C., Liu, K., Tempel, W., Demetriades, M., Aik, W., Schofield, C.J., Min, J.
J.Biol.Chem.