CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.60 | Sandwich | |
2.60.120 | Jelly Rolls | |
2.60.120.590 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
Domain Context
CATH Clusters
Superfamily | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
Functional Family | RNA demethylase ALKBH5 |
Enzyme Information
1.14.11.53 |
mRNA N(6)-methyladenine demethylase.
based on mapping to UniProt Q6P6C2
N(6)-methyladenosine in mRNA + 2-oxoglutarate + O(2) = adenosine in mRNA + formaldehyde + succinate + CO(2).
-!- Catalyzes oxidative demethylation of mRNA N(6)-methyladenine. -!- The FTO enzyme from human can also demethylate N(3)-methylthymine from single stranded DNA and N(3)-methyluridine from single stranded RNA with low activity.
|
UniProtKB Entries (1)
Q6P6C2 |
ALKB5_HUMAN
Homo sapiens
RNA demethylase ALKBH5
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PDB Structure
PDB | 4OCT |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
J.Biol.Chem.
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