CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.132.70
Functional Family Telomerase reverse transcriptase

Enzyme Information

2.7.7.49
RNA-directed DNA polymerase.
based on mapping to UniProt Q1PS67
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.

UniProtKB Entries (1)

Q1PS67
TERT_ORYLA
Oryzias latipes
Telomerase reverse transcriptase

PDB Structure

PDB 4O26
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for protein-RNA recognition in telomerase.
Huang, J., Brown, A.F., Wu, J., Xue, J., Bley, C.J., Rand, D.P., Wu, L., Zhang, R., Chen, J.J., Lei, M.
Nat.Struct.Mol.Biol.