CATH Domain 4o02A03

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.1510	ntegrin, alpha v. Chain A, domain 3

Domain Context

CATH Clusters

Superfamily	ntegrin, alpha v. Chain A, domain 3
Functional Family	Integrin alpha V

Enzyme Information

UniProtKB Entries (1)

ITB3_HUMAN

Homo sapiens

Integrin beta-3

PDB Structure

PDB	4O02
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Atomic basis for the species-specific inhibition of alpha V integrins by monoclonal antibody 17E6 is revealed by the crystal structure of alpha V beta 3 ectodomain-17E6 Fab complex. Mahalingam, B., Van Agthoven, J.F., Xiong, J.P., Alonso, J.L., Adair, B.D., Rui, X., Anand, S., Mehrbod, M., Mofrad, M.R., Burger, C., Goodman, S.L., Arnaout, M.A. J.Biol.Chem.