CATH Domain 4nyiS02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.840	Son of Sevenless (SoS) protein; Chain S, domain 2
	1.10.840.10	Ras guanine-nucleotide exchange factors catalytic domain

Domain Context

CATH Clusters

Superfamily	Ras guanine-nucleotide exchange factors catalytic domain
Functional Family	son of sevenless homolog 1 isoform X2

Enzyme Information

UniProtKB Entries (1)

RASH_HUMAN

Homo sapiens

GTPase HRas

PDB Structure

PDB	4NYI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange. Burns, M.C., Sun, Q., Daniels, R.N., Camper, D., Kennedy, J.P., Phan, J., Olejniczak, E.T., Lee, T., Waterson, A.G., Rossanese, O.W., Fesik, S.W. Proc.Natl.Acad.Sci.USA