CATH Domain 4ny9A00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.565	Retinoid X Receptor
	1.10.565.10	Retinoid X Receptor

Domain Context

CATH Clusters

Superfamily	Retinoid X Receptor
Functional Family	Nuclear receptor subfamily 1 group I member 2

Enzyme Information

UniProtKB Entries (1)

NR1I2_HUMAN

Homo sapiens

Nuclear receptor subfamily 1 group I member 2

PDB Structure

PDB	4NY9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis. Santella, J.B., Gardner, D.S., Duncia, J.V., Wu, H., Dhar, M., Cavallaro, C., Tebben, A.J., Carter, P.H., Barrish, J.C., Yarde, M., Briceno, S.W., Cvijic, M.E., Grafstrom, R.R., Liu, R., Patel, S.R., Watson, A.J., Yang, G., Rose, A.V., Vickery, R.D., Caceres-Cortes, J., Caporuscio, C., Camac, D.M., Khan, J.A., An, Y., Foster, W.R., Davies, P., Hynes, J. J.Med.Chem.