CATH Domain 4nxsB02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.1180	Golgi alpha-mannosidase II

Domain Context

CATH Clusters

Superfamily	Golgi alpha-mannosidase II
Functional Family	Alpha-galactosidase A

Enzyme Information

3.2.1.22

Alpha-galactosidase.

based on mapping to UniProt P06280

Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha- D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.

-!- Also hydrolyzes alpha-D-fucosides.

UniProtKB Entries (1)

P06280

AGAL_HUMAN

Homo sapiens

Alpha-galactosidase A

PDB Structure

PDB	4NXS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Molecular Basis of 1-Deoxygalactonojirimycin Arylthiourea Binding to Human alpha-Galactosidase A: Pharmacological Chaperoning Efficacy on Fabry Disease Mutants. Yu, Y., Mena-Barragan, T., Higaki, K., Johnson, J.L., Drury, J.E., Lieberman, R.L., Nakasone, N., Ninomiya, H., Tsukimura, T., Sakuraba, H., Suzuki, Y., Nanba, E., Mellet, C.O., Garcia Fernandez, J.M., Ohno, K. Acs Chem.Biol.