CATH Domain 4nj3A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Cyclin-dependent kinase 2

Enzyme Information

2.7.11.22

Cyclin-dependent kinase.

based on mapping to UniProt P24941

ATP + a protein = ADP + a phosphoprotein.

-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P24941

CDK2_HUMAN

Homo sapiens

Cyclin-dependent kinase 2

PDB Structure

PDB	4NJ3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor. Deng, Y., Shipps, G.W., Zhao, L., Siddiqui, M.A., Popovici-Muller, J., Curran, P.J., Duca, J.S., Hruza, A.W., Fischmann, T.O., Madison, V.S., Zhang, R., McNemar, C.W., Mayhood, T.W., Syto, R., Annis, A., Kirschmeier, P., Lees, E.M., Parry, D.A., Windsor, W.T. Bioorg.Med.Chem.Lett.