CATH Domain 4nalA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.550	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
	3.90.550.10	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A

Domain Context

CATH Clusters

Superfamily	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Enzyme Information

2.7.7.60

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.

based on mapping to UniProt P69834

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.

-!- ATP or UTP can replace CTP, but both are less effective. -!- GTP and TTP are not substrates. -!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

P69834

ISPD_ARATH

Arabidopsis thaliana

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic

PDB Structure

PDB	4NAL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD. Kunfermann, A., Witschel, M., Illarionov, B., Martin, R., Rottmann, M., Hoffken, H.W., Seet, M., Eisenreich, W., Knolker, H.J., Fischer, M., Bacher, A., Groll, M., Diederich, F. Angew.Chem.Int.Ed.Engl.