CATH Domain 4n5tA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.245	MDM2
	1.10.245.10	SWIB/MDM2 domain

Domain Context

CATH Clusters

Superfamily	SWIB/MDM2 domain
Functional Family

Enzyme Information

UniProtKB Entries (1)

MDM4_DANRE

Danio rerio

Protein Mdm4

PDB Structure

PDB	4N5T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Stapled alpha-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy. Chang, Y.S., Graves, B., Guerlavais, V., Tovar, C., Packman, K., To, K.H., Olson, K.A., Kesavan, K., Gangurde, P., Mukherjee, A., Baker, T., Darlak, K., Elkin, C., Filipovic, Z., Qureshi, F.Z., Cai, H., Berry, P., Feyfant, E., Shi, X.E., Horstick, J., Annis, D.A., Manning, A.M., Fotouhi, N., Nash, H., Vassilev, L.T., Sawyer, T.K. Proc.Natl.Acad.Sci.USA