1 keywords

CATH Domain 4n1uA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.79 Nucleoside Triphosphate Pyrophosphohydrolase
Homologous Superfamily 3.90.79.10 Nucleoside Triphosphate Pyrophosphohydrolase

Domain Context

CATH Clusters

Superfamily Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family 7,8-dihydro-8-oxoguanine triphosphatase

Enzyme Information

3.6.1.56
2-hydroxy-dATP diphosphatase.
based on mapping to UniProt P36639
2-hydroxy-dATP + H(2)O = 2-hydroxy-dAMP + diphosphate.
-!- The enzyme hydrolyzes oxidized purine nucleoside triphosphates such as 2-hydroxy-dATP, thereby preventing their misincorporation into DNA. -!- It can also recognize 8-oxo-dGTP and 8-oxo-dATP, but with lower efficiency (cf. EC 3.6.1.55).
3.6.1.55
8-oxo-dGTP diphosphatase.
based on mapping to UniProt P36639
8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.
-!- This enzyme hydrolyzes the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. -!- It does not hydrolyze 2-hydroxy-dATP (cf. EC 3.6.1.56).

UniProtKB Entries (1)

P36639
8ODP_HUMAN
Homo sapiens
7,8-dihydro-8-oxoguanine triphosphatase

PDB Structure

PDB 4N1U
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad, H., Koolmeister, T., Jemth, A.S., Eshtad, S., Jacques, S.A., Strom, C.E., Svensson, L.M., Schultz, N., Lundback, T., Einarsdottir, B.O., Saleh, A., Gokturk, C., Baranczewski, P., Svensson, R., Berntsson, R.P., Gustafsson, R., Stromberg, K., Sanjiv, K., Jacques-Cordonnier, M.C., Desroses, M., Gustavsson, A.L., Olofsson, R., Johansson, F., Homan, E.J., Loseva, O., Brautigam, L., Johansson, L., Hoglund, A., Hagenkort, A., Pham, T., Altun, M., Gaugaz, F.Z., Vikingsson, S., Evers, B., Henriksson, M., Vallin, K.S., Wallner, O.A., Hammarstrom, L.G., Wiita, E., Almlof, I., Kalderen, C., Axelsson, H., Djureinovic, T., Puigvert, J.C., Haggblad, M., Jeppsson, F., Martens, U., Lundin, C., Lundgren, B., Granelli, I., Jensen, A.J., Artursson, P., Nilsson, J.A., Stenmark, P., Scobie, M., Berglund, U.W., Helleday, T.
Nature