CATH Classification
Level | CATH Code | Description |
---|---|---|
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2 | Mainly Beta |
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2.120 | 6 Propeller |
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2.120.10 | Neuraminidase |
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2.120.10.10 |
Domain Context
CATH Clusters
Superfamily | 2.120.10.10 |
Functional Family |
Enzyme Information
3.2.1.18 |
Exo-alpha-sialidase.
based on mapping to UniProt P08492
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.
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UniProtKB Entries (1)
P08492 |
HN_PI3H4
Human parainfluenza 3 virus (strain NIH 47885)
Hemagglutinin-neuraminidase
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PDB Structure
PDB | 4MZA |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Interaction between the hemagglutinin-neuraminidase and fusion glycoproteins of human parainfluenza virus type III regulates viral growth in vivo.
MBio
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