CATH Classification
Level | CATH Code | Description |
---|---|---|
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2 | Mainly Beta |
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2.40 | Beta Barrel |
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2.40.10 | Thrombin, subunit H |
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2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
Superfamily | Trypsin-like serine proteases |
Functional Family | Tryptase gamma 1 |
Enzyme Information
3.4.21.59 |
Tryptase.
based on mapping to UniProt Q15661
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.
-!- Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. -!- Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin. -!- Belongs to peptidase family S1.
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UniProtKB Entries (1)
Q15661 |
TRYB1_HUMAN
Homo sapiens
Tryptase alpha/beta-1
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PDB Structure
PDB | 4MPV |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Target-Directed Self-Assembly of Homodimeric Drugs Against beta-Tryptase.
Acs Med.Chem.Lett.
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