CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.120 | Four Helix Bundle (Hemerythrin (Met), subunit A) |
|
1.20.120.1760 | CDP-alcohol phosphotransferase transmembrane (TM) domain |
Domain Context
CATH Clusters
| Superfamily | 1.20.120.1760 |
| Functional Family | Bifunctional IPC transferase and DIPP synthase |
Enzyme Information
| 2.7.8.34 |
CDP-L-myo-inositol myo-inositolphosphotransferase.
based on mapping to UniProt O29976
CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate = CMP + bis(1L-myo- inositol) 3,1'-phosphate 1-phosphate.
-!- In many organisms this activity is catalyzed by a bifunctional enzyme. -!- The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP- 1L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors. -!- The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3- phosphate, a widespread organic solute in microorganisms adapted to hot environments.
|
| 2.7.7.74 |
1L-myo-inositol 1-phosphate cytidylyltransferase.
based on mapping to UniProt O29976
CTP + 1L-myo-inositol 1-phosphate = diphosphate + CDP-1L-myo-inositol.
-!- In many organisms this activity is catalyzed by a bifunctional enzyme. -!- The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. -!- The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments. -!- In many organisms this activity is catalyzed by a bifunctional enzyme. -!- The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 is absolutely specific for CTP and 1L-myo- inositol 1-phosphate. -!- The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments.
|
UniProtKB Entries (1)
| O29976 |
DIPPS_ARCFU
Archaeoglobus fulgidus DSM 4304
Bifunctional IPC transferase and DIPP synthase
|
PDB Structure
| PDB | 4MND |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
X-ray structure of a CDP-alcohol phosphatidyltransferase membrane enzyme and insights into its catalytic mechanism.
Nat Commun
|
