CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.50 | OB fold (Dihydrolipoamide Acetyltransferase, E2P) |
|
2.40.50.150 | RNA polymerase II, Rpb2 subunit, wall domain |
Domain Context
CATH Clusters
| Superfamily | 2.40.50.150 |
| Functional Family | DNA-directed RNA polymerase subunit beta |
Enzyme Information
| 2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt P0A8V2
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
|
UniProtKB Entries (1)
| P0A7Z4 |
RPOA_ECOLI
Escherichia coli K-12
DNA-directed RNA polymerase subunit alpha
|
PDB Structure
| PDB | 4MEX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Transcription inhibition by the depsipeptide antibiotic salinamide A.
Elife
|
