CATH Domain 4mccA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1280	Alpha/beta knot
	3.40.1280.10	SPOUT methyltransferase, trefoil knot domain

Domain Context

CATH Clusters

Superfamily	3.40.1280.10
Functional Family	tRNA (guanine-N(1)-)-methyltransferase

Enzyme Information

2.1.1.228

tRNA (guanine(37)-N(1))-methyltransferase.

based on mapping to UniProt P43912

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.

-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

P43912

TRMD_HAEIN

Haemophilus influenzae Rd KW20

TRNA (guanine-N(1)-)-methyltransferase

PDB Structure

PDB	4MCC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain. Hill, P.J., Abibi, A., Albert, R., Andrews, B., Gagnon, M.M., Gao, N., Grebe, T., Hajec, L.I., Huang, J., Livchak, S., Lahiri, S.D., McKinney, D.C., Thresher, J., Wang, H., Olivier, N., Buurman, E.T. J.Med.Chem.