CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.1280 | Alpha/beta knot |
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3.40.1280.10 | SPOUT methyltransferase, trefoil knot domain |
Domain Context
CATH Clusters
Superfamily | 3.40.1280.10 |
Functional Family | tRNA (guanine-N(1)-)-methyltransferase |
Enzyme Information
2.1.1.228 |
tRNA (guanine(37)-N(1))-methyltransferase.
based on mapping to UniProt P43912
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.
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UniProtKB Entries (1)
P43912 |
TRMD_HAEIN
Haemophilus influenzae Rd KW20
TRNA (guanine-N(1)-)-methyltransferase
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PDB Structure
PDB | 4MCB |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.
J.Med.Chem.
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