CATH Domain 4m8tA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Ribosomal protein S6 kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P18654

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P18654

KS6A3_MOUSE

Mus musculus

Ribosomal protein S6 kinase alpha-3

PDB Structure

PDB	4M8T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Covalent docking of large libraries for the discovery of chemical probes. London, N., Miller, R.M., Krishnan, S., Uchida, K., Irwin, J.J., Eidam, O., Gibold, L., Cimermancic, P., Bonnet, R., Shoichet, B.K., Taunton, J. Nat.Chem.Biol.