CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family

Enzyme Information

4.2.3.37
Epi-isozizaene synthase.
based on mapping to UniProt Q9K499
(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate.
-!- The displacement of the diphosphate group of farnesyl diphosphate occurs with retention of configuration. -!- In the soil-dwelling bacterium Streptomyces coelicolor A3(2), the product of this reaction is used by EC 1.14.13.106 to produce the sesquiterpene antibiotic albaflavenone.

UniProtKB Entries (1)

Q9K499
CYC1_STRCO
Streptomyces coelicolor A3(2)
Epi-isozizaene synthase

PDB Structure

PDB 4LZ3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase.
Li, R., Chou, W.K., Himmelberger, J.A., Litwin, K.M., Harris, G.G., Cane, D.E., Christianson, D.W.
Biochemistry
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