CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.600 | Farnesyl Diphosphate Synthase |
|
1.10.600.10 | Farnesyl Diphosphate Synthase |
Domain Context
CATH Clusters
| Superfamily | Farnesyl Diphosphate Synthase |
| Functional Family |
Enzyme Information
| 4.2.3.37 |
Epi-isozizaene synthase.
based on mapping to UniProt Q9K499
(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate.
-!- The displacement of the diphosphate group of farnesyl diphosphate occurs with retention of configuration. -!- In the soil-dwelling bacterium Streptomyces coelicolor A3(2), the product of this reaction is used by EC 1.14.13.106 to produce the sesquiterpene antibiotic albaflavenone.
|
UniProtKB Entries (1)
| Q9K499 |
CYC1_STRCO
Streptomyces coelicolor A3(2)
Epi-isozizaene synthase
|
PDB Structure
| PDB | 4LZ0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase.
Biochemistry
|
