CATH Classification
Level | CATH Code | Description |
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2 | Mainly Beta |
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2.10 | Ribbon |
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2.10.25 | Laminin |
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2.10.25.10 | Laminin |
Domain Context
CATH Clusters
Superfamily | Laminin |
Functional Family | Mannan-binding lectin serine protease 1 |
Enzyme Information
3.4.21.42 |
Complement subcomponent C1s.
based on mapping to UniProt P09871
Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.
-!- Activated from proenzyme C1s in plasma by the activated complement subcomponent C1r. -!- Belongs to peptidase family S1.
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UniProtKB Entries (1)
P09871 |
C1S_HUMAN
Homo sapiens
Complement C1s subcomponent
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PDB Structure
PDB | 4LOR |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation.
Proc.Natl.Acad.Sci.USA
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