CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.590 | Creatine Kinase; Chain A, domain 2 |
|
3.30.590.10 | Glutamine synthetase/guanido kinase, catalytic domain |
Domain Context
CATH Clusters
| Superfamily | Glutamine synthetase/guanido kinase, catalytic domain |
| Functional Family | Glutamine synthetase 2 |
Enzyme Information
| 6.3.1.2 |
Glutamine synthetase.
based on mapping to UniProt P12425
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.
-!- Glutamine synthetase, which catalyzes the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life. -!- Several types have been described, differing in their oligomeric structures and cofactor requirements.
|
UniProtKB Entries (1)
| P12425 |
GLN1A_BACSU
Bacillus subtilis subsp. subtilis str. 168
Glutamine synthetase
|
PDB Structure
| PDB | 4LNK |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structures of the Bacillus subtilis Glutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism.
J.Biol.Chem.
|