CATH Domain 4le9A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.30	SH3 type barrels.
	2.30.30.40	SH3 Domains

Domain Context

CATH Clusters

Superfamily	SH3 Domains
Functional Family

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P00523

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00523

SRC_CHICK

Gallus gallus

Proto-oncogene tyrosine-protein kinase Src

PDB Structure

PDB	4LE9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	3D domain swapping in a chimeric c-Src SH3 domain takes place through two hinge loops. Camara-Artigas, A., Martinez-Rodriguez, S., Ortiz-Salmeron, E., Martin-Garcia, J.M. J.Struct.Biol.