CATH Domain 4l8zA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.565	Heat Shock Protein 90
	3.30.565.10	Histidine kinase-like ATPase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Histidine kinase-like ATPase, C-terminal domain
Functional Family	Heat shock protein HSP 90-alpha

Enzyme Information

UniProtKB Entries (1)

HS90A_HUMAN

Homo sapiens

Heat shock protein HSP 90-alpha

PDB Structure

PDB	4L8Z
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization Ren, J., Li, J., Wang, Y., Chen, W., Shen, A., Liu, H., Chen, D., Cao, D., Li, Y., Zhang, N., Xu, Y., Geng, M., He, J., Xiong, B., Shen, J. Bioorg.Med.Chem.Lett.