CATH Domain 4l3qA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.40	ATPase, nucleotide binding domain

Domain Context

CATH Clusters

Superfamily	3.30.420.40
Functional Family	Phosphotransferase

Enzyme Information

2.7.1.2

Glucokinase.

based on mapping to UniProt P35557

ATP + D-glucose = ADP + D-glucose 6-phosphate.

-!- A group of enzymes found in invertebrates and microorganisms highly specific for glucose.

UniProtKB Entries (1)

HXK4_HUMAN

Homo sapiens

Glucokinase

PDB Structure

PDB	4L3Q
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif. Filipski, K.J., Guzman-Perez, A., Bian, J., Perreault, C., Aspnes, G.E., Didiuk, M.T., Dow, R.L., Hank, R.F., Jones, C.S., Maguire, R.J., Tu, M., Zeng, D., Liu, S., Knafels, J.D., Litchfield, J., Atkinson, K., Derksen, D.R., Bourbonais, F., Gajiwala, K.S., Hickey, M., Johnson, T.O., Humphries, P.S., Pfefferkorn, J.A. Bioorg.Med.Chem.Lett.