CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P23458
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P23458
JAK1_HUMAN
Homo sapiens
Tyrosine-protein kinase JAK1

PDB Structure

PDB 4L01
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases.
Toms, A.V., Deshpande, A., McNally, R., Jeong, Y., Rogers, J.M., Kim, C.U., Gruner, S.M., Ficarro, S.B., Marto, J.A., Sattler, M., Griffin, J.D., Eck, M.J.
Nat.Struct.Mol.Biol.