CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.572 | Thymidylate Synthase; Chain A |
|
3.30.572.10 | Thymidylate synthase/dCMP hydroxymethylase domain |
Domain Context
CATH Clusters
| Superfamily | Thymidylate synthase/dCMP hydroxymethylase domain |
| Functional Family | Possible thymidylate synthase |
Enzyme Information
| 2.1.1.45 |
Thymidylate synthase.
based on mapping to UniProt Q07422
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
|
| 1.5.1.3 |
Dihydrofolate reductase.
based on mapping to UniProt Q07422
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.
|
UniProtKB Entries (1)
| Q07422 |
DRTS_TOXGO
Toxoplasma gondii
Bifunctional dihydrofolate reductase-thymidylate synthase
|
PDB Structure
| PDB | 4KY4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections.
ACS Med Chem Lett
|
